SōRSE & Pascal Optimize Cannabinoid Formulation for Development of Cancer Treatment

Pascal Biosciences and SōRSE Technology Optimize Cannabinoid Formulation for Clinical Development of Cancer Treatment

SEATTLE & VANCOUVER, British Columbia–Pascal Biosciences Inc. (TSX.V:PAS) (OTC:BIMUF) (“Pascal” or the “Company”) and SōRSE Technology Corporation (“SōRSE”) have validated and optimized a formula for oral cannabinoid delivery. Their shared efforts are advancing the cannabinoid PAS-393 towards clinical testing against cancer.

“This progress is very promising because this step is critical for testing in human volunteers,” said Pascal CEO Patrick Gray. “We will next identify a drug product manufacturer to prepare our product for testing in cancer patients treated with checkpoint inhibitors.”

It will be the first pharmaceutical use of the novel formulation technology developed by SōRSE and the first clinical trial for Pascal and SōRSE. This collaboration utilizes propriety discoveries by both companies, including Pascal’s intellectual property, which covers the use of cannabinoids in cancer patients treated with checkpoint inhibitors, and SōRSE’s proprietary formulation expertise.

“It’s great to see such rapid progress with the in vitro studies using our formulation technology,” said SōRSE CEO Howard Lee. “We are on track to enter our first clinical trial with Pascal within a year.”

Following characterization of safety and pharmacology in a Phase 1a clinical trial, Pascal and SōRSE may elect to continue clinical development as equal partners in a Phase 1b cancer trial in combination with a checkpoint inhibitor.

About Pascal Biosciences Inc.

Pascal is a biotechnology company targeting innovative therapies for serious diseases, including COVID-19. Pascal is also developing treatments for cancer with targeted therapies for acute lymphoblastic leukemia and cannabinoid-based therapeutics. Pascal’s leading portfolio also comprises a small molecule therapeutic, PAS-403, that is advancing into clinical trials for the treatment of glioblastoma, and PAS-393, an immuno-stimulatory cannabinoid to be used in combination with checkpoint inhibitor therapy. For more information, visit www.pascalbiosciences.com.

About SōRSE Technology

SōRSE Technology Corporation is a water-soluble emulsion technology designed for product developers to provide consumers with a better, more consistent cannabinoid experience with greater bioavailability, near-perfect dosing, shelf-stability, and safe ingredients. Its patent-pending technology converts oil into SōRSE, a proprietary water-soluble emulsion, for infusing CBD and other functional ingredients into beverages, food items, topicals, and medical applications. SōRSE Technology currently powers more than 45 leading products in the CBD space. For more information, visit www.sorsetechnology.com.

Contacts

SōRSE Technology Press:
Jon Lindsay Phillips
RLM PR
SorseTech@rlmpr.com
+1-646-828-8566

SōRSE Brings CBD Water-Soluble Emulsion Tech to Colombia with Joint Venture with FCM Global

SoRSE by FCM Global

SEATTLE–SōRSE Technology, the leading water-soluble CBD, hemp, and terpene emulsion provider for infused CPG brands, has announced a joint venture with FCM Global to incorporate a new company in Colombia, drawing on their respective expertise in the cannabis marketplace.

The announcement was made at the Asocolocanna 2nd Forum, the largest cannabis-focused, three-day conference in Colombia, with 400 attendees from government, industry, academia, and research institutes. Four Colombian ministries were represented at the conference: Health and Social Protection, Justice and Law, Sports and Commerce, and Industry and Tourism. Also in attendance were members of other Latin American cannabis associations, including Mexico, Peru, Uruguay, Paraguay, and Argentina. SōRSE Technology was a Platinum Sponsor of the event, and 80 percent of conference-goers attended SōRSE’s VP of Technical Business Development Michael Flemmen’s presentation on water-soluble solutions for infused beverages.

By entering into a joint venture with FCM, SōRSE will now possess a license to apply its technology to THC, CBD, and other cannabinoids in Colombia, as well as a manner in which to export products featuring SōRSE emulsion from Colombia throughout other Central and South American countries. The emulsion will be branded as “SōRSE by FCM GLOBAL.”

“With SōRSE Technology joining FCM Global, the top supplier of cannabis oils, extracts, and isolates, Latin America customers will receive the same low production costs and high quality they have come to expect from FCM – now with water-soluble solutions,” commented Alejandro Marin, Co-Founder and CFO of FCM Global.

FCM Global has committed to providing all required licenses and permits to produce cannabis derivatives in Colombia, working environment, and all labor required for production of SōRSE emulsion. FCM Global will monitor all sales and outreach operations to sell SōRSE and will supply CBD oil (broad-spectrum, distillate, etc.) for conversion to SōRSE products at the current production cost for FCM.

“SōRSE by FCM GLOBAL will deliver safe, stable, and scalable ingredients for Latin America’s product development needs, such as cosmetics, topicals, edibles and pet products,” said Felipe Sanchez, SōRSE Technology’s VP for Latin America. “We are excited to be working in partnership with FCM on this venture and entering into the Latin American marketplace.”

SōRSE has agreed to provide intellectual property, know-how, and equipment to build a SōRSE lab in Colombia, and technical support in sales efforts.

About FCM Global

Company HQ in Medellin, Colombia. Produces organic hemp and cannabis oils, extracts and isolates using its “Co-Sourced Colombia” model to reliably deliver lower production costs and high-quality inputs for domestics and international markets in the nutritional, wellness, pharmaceutical and cosmetic sectors.

Production facilities located in Antioquia and Tolima follow GAP and GMP practices. The 238,800 ft2 FCM Antioquia facility is purpose-built for medical cannabis and the Tolima facility is an extended production facility that covers 474 hectares and will, at full capacity, generate more than 2,300 jobs and 1,000+ tons of cannabis oil per year. This will provide customers with the best and most consistent quality products with lower production cost at large scale.

FCM Global has made the strategic decision and commitment to not compete with our finished product manufacturing clients. Instead, we focus 100% on helping lower our clients’ cost of production by producing/supplying custom CBD extracts, oils, and isolates from Colombia which meet their specific product requirements and support their future new product innovations.

About SōRSE Technology

SōRSE Technology Corporation is a water-soluble emulsion technology designed for product developers to provide consumers with a better, more consistent cannabinoid experience with greater bioavailability, near-perfect dosing, shelf-stability, and safe ingredients. Its patent-pending technology converts oil into SōRSE, a proprietary water-soluble emulsion, for infusing CBD and other functional ingredients into beverages, food items, topicals, and medical applications. SōRSE Technology currently powers more than 45 leading products in the CBD space.

SōRSE is the most consistent, stable, and safe water-soluble solution for integrating CBD and hemp into commercially available products – but it’s also customizable. Our R&D team collaborates with our partners to develop signature formulations that achieve a desired flavor, aroma, or effect to complement each product.

SōRSE implements Good Manufacturing Practices (GMP) and conducts internal and 3rd party testing to produce a Certificate of Analysis for all final materials.

Contacts

Media Contact/SōRSE Technology Press
Jon Lindsay Phillips
RLM PR
SorseTech@rlmpr.com
+1-646-828-8566

Pascal & SōRSE Announce Partnership for Cannabinoid Drug Development

Biotech Company Pascal Biosciences and SōRSE Technology Announce Partnership for Cannabinoid Drug Development and Cancer Clinical Trials
SEATTLE & VANCOUVER, British Columbia–(BUSINESS WIRE)–Pascal Biosciences Inc. (TSX.V:PAS) (“Pascal”) and SōRSE Technology Corporation (“SōRSE”) have entered into a Collaborative Research Agreement to advance Pascal’s PAS-393 into clinical testing. Pascal and SōRSE will share their respective technologies to test the cannabinoid PAS-393 in human volunteers, enabling testing of cancer patients treated with checkpoint inhibitors.

 

SōRSE currently sells and licenses a proprietary water-soluble cannabinoid emulsion technology (patent-pending) that enables increased bioavailability, accurate dosing, and more than 12 months’ shelf stability. Pascal and SōRSE scientists will optimize a cannabinoid formulation for human subjects and will then test the formulated PAS-393 in volunteers. SōRSE will provide $750,000 in research funding to Pascal throughout the 15-month collaboration and will pay for related research expenditures.

Following characterization of safety and pharmacology in a Phase 1a clinical trial, Pascal and SōRSE may elect to continue clinical development as equal partners in a Phase 1b cancer trial in combination with a checkpoint inhibitor. Dr. Gray will present scientific data this September 15th at the 3rd Annual International Cannabinoid-Derived Pharmaceutical Conference occurring in Boston, MA; the topic of his presentation is “Identifying and Validating Mechanism of Action In vivo/vitro.”

 

“At SōRSE, we’re driven by our mission to help people better their lives through superior cannabinoid ingredients and delivery methods,” said SōRSE CEO Howard Lee. “We were thrilled when Pascal Biosciences reached out to us in the summer of 2019 asking to use our emulsion in their research study on immune recognition markers on cancer cells. Today, we are excited to continue to support pharmaceutical studies of cannabinoids with Pascal and other world-class researchers.

 

”SōRSE intends to collaborate with other researchers and product developers to study cannabinoids in other medical applications. Pascal will continue to pursue other non-cancer indications for PAS-393.

“This is an impressive step forward for both Pascal and SōRSE, and hopefully our product will be a significant help to patients,” commented Dr. Patrick Gray, CEO of Pascal Biosciences. “This will be the first clinical trial for each company, and we look forward to a long, fruitful relationship.”

About Pascal Biosciences Inc.

Pascal is a biotechnology company targeting innovative therapies for serious diseases, including COVID-19. Pascal is also developing treatments for cancer with targeted therapies for acute lymphoblastic leukemia and cannabinoid-based therapeutics. Pascal’s leading portfolio also comprises a small molecule therapeutic, PAS-403, that is advancing into clinical trials for the treatment of glioblastoma, and PAS-393, an immuno-stimulatory cannabinoid to be used in combination with checkpoint inhibitor therapy. For more information, visit www.pascalbiosciences.com.

About PAS-393

Pascal recently discovered the unique capacity of its cannabinoid drug, PAS-393, to reverse a common immune-evading strategy adopted by many metastatic cancers. Thus, treatment with PAS-393 may restore the ability of the immune system to recognize and eliminate cancer cells. This activity is especially important for immune checkpoint inhibitors, which depend upon immune recognition of cancer for their efficacy. Pascal is advancing PAS-393 as a combination therapy with checkpoint inhibitors for the 50% or more of cancer patients not currently helped by the checkpoint inhibitors.

About SōRSE Technology Corporation

SōRSE Technology Corporation is a water-soluble emulsion technology designed for product developers to provide consumers with a better, more consistent cannabinoid experience with greater bioavailability, near-perfect dosing, shelf-stability, and safe ingredients. Its patent-pending technology converts oil into SōRSE, a proprietary water-soluble emulsion, for infusing CBD and other functional ingredients into beverages, food items, topicals, and medical applications. SōRSE Technology currently powers more than 45 leading products in the CBD space.

Contacts

SōRSE Technology Press:
Jon Lindsay Phillips
RLM PR
SorseTech@rlmpr.com
+1-646-828-8566